Adequan vs. Legend — What's the Difference?

Adequan is primarily known for its ability to stimulate cartilage repair and reverse joint damage, making it a disease-modifying osteoarthritis drug (DMOAD). It is administered through intramuscular injections directly targeting affected joints. On the other hand, Legend works as an anti-inflammatory agent, reducing the symptoms of osteoarthritis by inhibiting inflammatory processes. It is given intravenously, offering a systemic approach to managing joint pain and inflammation.

Adequan's active ingredient, polysulfated glycosaminoglycan, is designed to enhance the production of joint lubricating fluids and support the repair of damaged cartilage. This makes it particularly effective in the early stages of osteoarthritis. Whereas, Legend's active component, hyaluronate sodium, works by improving the quality of the synovial fluid, thereby reducing friction and enhancing joint function, making it beneficial at various stages of joint issues.

The treatment regimen for Adequan typically involves a series of injections over a specific period, which can provide long-term benefits to the joint structure and function. Conversely, Legend may require less frequent administration, focusing on immediate relief from acute inflammation and pain, which can be particularly useful during flare-ups of osteoarthritis.

Adequan is often recommended for horses with more advanced joint degradation or for those where there is a clear need for cartilage repair and regeneration. In contrast, Legend is usually preferred for managing acute episodes of joint pain and swelling, making it a go-to for immediate relief rather than long-term joint health.

While Adequan's effects are localized to the joints treated and can lead to visible improvements in joint health over time, Legend's systemic approach means it can address inflammation throughout the body, providing broad relief from osteoarthritis symptoms without specifically targeting joint repair.