Advil vs. Tylenol — What's the Difference?
Edited by Tayyaba Rehman — By Maham Liaqat — Updated on May 14, 2024
Advil, with ibuprofen as its active ingredient, targets inflammation and pain; Tylenol, containing acetaminophen, primarily alleviates pain and reduces fever without addressing inflammation.
Difference Between Advil and Tylenol
Table of Contents
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Key Differences
Advil (ibuprofen) is effective in treating pain, fever, and inflammation, making it suitable for conditions like arthritis and sprains, whereas Tylenol (acetaminophen) is preferred for relieving pain and reducing fever but is less effective at treating inflammation.
Advil works by inhibiting the production of prostaglandins, substances in the body that promote inflammation, pain, and fever, on the other hand, Tylenol acts primarily in the brain to reduce pain and fever, without significantly affecting inflammation.
While Advil is often recommended for shorter durations due to its potential side effects on the stomach and kidneys, Tylenol is generally considered safer for regular use over longer periods, provided the recommended dosage is not exceeded to avoid liver damage.
For those with certain health conditions such as gastrointestinal issues or kidney disease, Tylenol may be a safer choice because it is gentler on the stomach and has less impact on kidney function, whereas Advil should be used cautiously.
Both medications are available over the counter and are commonly used worldwide, but it's essential to choose based on specific health needs and consult with a healthcare provider when unsure.
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Comparison Chart
Active Ingredient
Ibuprofen
Acetaminophen
Main Uses
Pain, inflammation, fever
Pain, fever (not inflammation)
Mechanism of Action
Inhibits prostaglandins production
Acts centrally in the brain
Side Effects
Gastrointestinal, kidney issues
Liver damage (overdose risk)
Duration of Use
Short-term due to side effects
Generally safer for longer use
Compare with Definitions
Advil
Available over the counter in various forms including tablets and liquid gels.
He prefers Advil liquid gels for quicker relief.
Tylenol
Considered safe for regular use if the dosage is carefully followed to avoid liver damage.
She takes Tylenol regularly for chronic pain, monitoring her dosage closely.
Advil
Can be used to treat conditions like arthritis, menstrual cramps, and minor injuries.
Advil is often recommended for its anti-inflammatory properties after sports injuries.
Tylenol
A brand of acetaminophen effective in relieving pain and reducing fever.
Tylenol is often given to children for its safety profile in managing fever.
Advil
A brand of ibuprofen used to reduce fever, pain, and inflammation.
She took Advil to alleviate her swollen ankle.
Tylenol
Does not treat inflammation, making it less suitable for conditions like arthritis.
Tylenol helped relieve his headache, but not the inflammation in his joints.
Advil
Should be used with caution by individuals with kidney issues or ulcers.
His doctor advised against Advil due to his kidney condition.
Tylenol
Safer for pregnant women compared to other over-the-counter pain relievers.
Tylenol is often the first choice for treating mild pains during pregnancy.
Advil
Not recommended for use during pregnancy, especially in the third trimester.
She switched from Advil to Tylenol during her pregnancy upon her doctor's recommendation.
Tylenol
Available in various forms, including chewable tablets and syrups for children.
Tylenol syrup is easy to administer to kids who dislike pills.
Advil
A nonsteroidal anti-inflammatory medicine used to relieve the pain of arthritis and as an analgesic and antipyretic; Advil and Motrin and Nuprin are trademarks of brands of ibuprofen tablets.
Tylenol
A tablet containing this drug
Advil
A nonsteroidal anti-inflammatory medicine (trade names Advil and Motrin and Nuprin) used to relieve the pain of arthritis and as an analgesic and antipyretic
Tylenol
An analgesic for mild pain; also used as an antipyretic; (Datril and Tylenol and Panadol and Phenaphen and Tempra and Anacin III are trademarks of brands of acetaminophen tablets)
Common Curiosities
Which is safer for long-term use, Advil or Tylenol?
Tylenol is generally safer for long-term use when dosages are strictly followed, especially for those with stomach or kidney concerns.
Is Advil or Tylenol better for headaches?
Both can be effective for headaches, but Tylenol is often the first choice due to its safety profile.
Which medication should be avoided during pregnancy?
Advil should generally be avoided during pregnancy, particularly in the third trimester, while Tylenol is safer for use.
Are there any age restrictions for using Advil or Tylenol?
Both medications can be used in children, but dosages must be adjusted according to age and weight.
How does Tylenol affect the liver?
Overuse or high doses of Tylenol can lead to liver damage.
What are the side effects of taking Advil?
Potential side effects include gastrointestinal issues and kidney problems.
What is the key difference in the action of Advil and Tylenol?
Advil reduces inflammation along with pain and fever, whereas Tylenol focuses on pain and fever without treating inflammation.
Can Advil and Tylenol be taken together?
Yes, taking Advil and Tylenol together is generally safe and can effectively manage pain and fever. However, it's best to consult a healthcare provider first.
Can Advil be used for menstrual cramps?
Yes, Advil is effective in treating menstrual cramps due to its anti-inflammatory properties.
Can Tylenol be taken on an empty stomach?
Yes, Tylenol can be taken on an empty stomach as it is not as harsh on the gastrointestinal tract.
Is Tylenol effective in reducing fever in children?
Yes, Tylenol is commonly used to reduce fever in children due to its efficacy and safety.
What should be considered before choosing between Advil and Tylenol?
Consider any existing health conditions, such as liver or kidney disease, and consult a healthcare provider.
How quickly does Tylenol start working?
Tylenol typically begins to relieve pain within 30 to 60 minutes of ingestion.
Can Advil cause ulcers?
Yes, prolonged use of Advil can increase the risk of developing stomach ulcers.
Who should not take Advil?
Individuals with ulcers, severe heart conditions, or advanced kidney disease should avoid Advil.
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Written by
Maham Liaqat
Edited by
Tayyaba RehmanTayyaba Rehman is a distinguished writer, currently serving as a primary contributor to askdifference.com. As a researcher in semantics and etymology, Tayyaba's passion for the complexity of languages and their distinctions has found a perfect home on the platform. Tayyaba delves into the intricacies of language, distinguishing between commonly confused words and phrases, thereby providing clarity for readers worldwide.
