Celexa vs. Lexapro — What's the Difference?
By Tayyaba Rehman — Published on December 10, 2023
Celexa (citalopram) and Lexapro (escitalopram) are both antidepressants in the SSRI class. Lexapro is essentially an updated version of Celexa, with potential for fewer side effects and arguably greater efficacy.
Difference Between Celexa and Lexapro
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Key Differences
Celexa, known by its generic name citalopram, and Lexapro, with the generic name escitalopram, both belong to the class of drugs called selective serotonin reuptake inhibitors (SSRIs). These medications are commonly prescribed to treat depression and certain anxiety disorders. Both work by increasing the levels of serotonin, a neurotransmitter in the brain that affects mood.
However, there's a significant chemical distinction between Celexa and Lexapro. Citalopram (Celexa) is a racemic compound, which means it consists of a 50/50 mixture of two enantiomers, or mirror image molecules. On the other hand, escitalopram (Lexapro) is only one of these enantiomers, specifically the S-enantiomer, which is believed to have the therapeutic effect.
Because Lexapro is a more refined version of Celexa, some studies suggest that it might offer advantages in terms of efficacy and side effects. Since Lexapro consists solely of the active S-enantiomer, it is sometimes considered to be more potent than Celexa, allowing for lower dosages with similar therapeutic effects. Additionally, this refinement might contribute to fewer side effects in some patients when using Lexapro compared to Celexa.
It's essential to note that both Celexa and Lexapro are effective treatments for depression and certain anxiety disorders, but individual reactions can vary. Some patients may respond better to one medication over the other, emphasizing the importance of personalized medical guidance. The decision between Celexa and Lexapro should be made collaboratively between a patient and their healthcare provider, considering the individual's specific needs and potential side effects.
Comparison Chart
Generic Name
Citalopram
Escitalopram
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Drug Class
Selective Serotonin Reuptake Inhibitor
Selective Serotonin Reuptake Inhibitor
Chemical Structure
Racemic compound (50/50 mix)
S-enantiomer of citalopram
Potency
Considered less potent than Lexapro
Generally more potent than Celexa
Common Side Effects
Potential for more side effects
Potential for fewer side effects
Compare with Definitions
Celexa
A medication used to treat certain anxiety disorders.
Celexa was recommended for his generalized anxiety disorder.
Lexapro
Used to manage specific anxiety conditions.
For panic disorder, her psychiatrist suggested Lexapro.
Celexa
A drug that increases serotonin levels in the brain.
Celexa can balance serotonin and potentially improve mood.
Lexapro
A medication that elevates serotonin in the brain.
By taking Lexapro, he hopes to stabilize his serotonin levels.
Celexa
A racemic compound of two enantiomers.
As a racemic drug, Celexa contains both S and R forms of the molecule.
Lexapro
An antidepressant in the SSRI category.
Lexapro was effective in treating her depressive symptoms.
Celexa
An antidepressant drug belonging to the SSRI class.
My doctor prescribed Celexa to help manage my depression.
Lexapro
The brand name for escitalopram.
He was previously on citalopram but found better results with Lexapro.
Celexa
The brand name for citalopram.
She switched from generic citalopram to branded Celexa.
Lexapro
The S-enantiomer of citalopram.
Lexapro, being the S-enantiomer, might offer fewer side effects than its counterpart.
Common Curiosities
What are Celexa and Lexapro primarily used for?
Both Celexa and Lexapro are primarily used to treat depression and certain anxiety disorders.
Are the side effects of Celexa and Lexapro similar?
While they share many common side effects as SSRIs, Lexapro is sometimes associated with fewer side effects.
Which is newer, Celexa or Lexapro?
Lexapro is a newer medication compared to Celexa.
Are Celexa and Lexapro the same drug?
No, while they are both SSRIs, Celexa is citalopram and Lexapro is escitalopram.
Can both medications be used for anxiety?
Yes, both Celexa and Lexapro are prescribed for certain anxiety disorders.
How do Celexa and Lexapro affect serotonin?
Both drugs increase serotonin levels in the brain, aiding in mood regulation.
Is one more potent than the other?
Lexapro is often considered more potent, allowing for potentially lower dosages for similar effects.
How long do Celexa and Lexapro take to show effects?
It can take several weeks for the full therapeutic effects to manifest.
Why is Lexapro considered more refined?
Lexapro consists solely of the active S-enantiomer, whereas Celexa has both enantiomers.
Is it common for patients to switch between Celexa and Lexapro?
Some patients switch based on efficacy or side effects, under medical guidance.
Are there any significant drug interactions with Celexa or Lexapro?
Both can have interactions with certain drugs, so it's essential to consult with a healthcare provider.
Are there generic versions available for both?
Yes, citalopram is the generic for Celexa, and escitalopram is the generic for Lexapro.
Can both drugs be taken during pregnancy?
Any medication use during pregnancy should be discussed with a healthcare provider.
Do Celexa and Lexapro have withdrawal symptoms?
Yes, discontinuation can lead to withdrawal symptoms; it's crucial not to stop suddenly without medical advice.
Which is more expensive, Celexa or Lexapro?
Prices can vary, but brand-name Lexapro might be more expensive than brand-name Celexa.
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Written by
Tayyaba RehmanTayyaba Rehman is a distinguished writer, currently serving as a primary contributor to askdifference.com. As a researcher in semantics and etymology, Tayyaba's passion for the complexity of languages and their distinctions has found a perfect home on the platform. Tayyaba delves into the intricacies of language, distinguishing between commonly confused words and phrases, thereby providing clarity for readers worldwide.
