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Magnesium Oxide vs. Magnesium Glycinate — What's the Difference?

By Tayyaba Rehman — Published on October 19, 2023
Magnesium Oxide is an inorganic compound used as an antacid and laxative. Magnesium Glycinate is a chelated form of magnesium used for better absorption. Both are magnesium salts but have different uses and benefits.
Magnesium Oxide vs. Magnesium Glycinate — What's the Difference?

Difference Between Magnesium Oxide and Magnesium Glycinate

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Key Differences

Magnesium Oxide: This is a white, inorganic compound commonly utilized for its antacid properties, aiding in the reduction of stomach acidity. In parallel, Magnesium Glycinate offers a more bioavailable form of magnesium, serving nutritional and therapeutic purposes.
Magnesium Glycinate: Formed from magnesium and the amino acid glycine, Magnesium Glycinate is often recommended for those seeking magnesium supplementation. It's known for being gentler on the stomach compared to Magnesium Oxide, which can sometimes cause digestive discomfort.
Absorption and Use: Magnesium Oxide, while containing a high percentage of magnesium, isn't as readily absorbed by the body as Magnesium Glycinate. The latter's enhanced absorption rate makes it a preferred choice for individuals wanting to address magnesium deficiencies.
Applications: Magnesium Oxide's primary applications revolve around its role as an antacid and laxative. On the other hand, Magnesium Glycinate is frequently used as a dietary supplement, beneficial for sleep, mood, and overall wellbeing.
Bioavailability: The body's ability to utilize Magnesium Glycinate is significantly better than Magnesium Oxide. While both offer magnesium, their differences in bioavailability and primary uses make them unique in their respective roles.
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Comparison Chart

Chemical Composition

Inorganic compound
Chelated form of magnesium with glycine

Main Use

Antacid and laxative
Dietary supplement

Absorption Rate

Lower
Higher

Gastrointestinal Effect

Can cause digestive discomfort
Gentler on the stomach

Bioavailability

Lesser
Enhanced

Compare with Definitions

Magnesium Oxide

Can function as a laxative.
Magnesium Oxide is sometimes prescribed to alleviate constipation.

Magnesium Glycinate

Renowned for enhanced bioavailability.
Those with magnesium deficiencies often opt for Magnesium Glycinate.

Magnesium Oxide

A white inorganic compound.
Magnesium Oxide tablets can neutralize excess stomach acid.

Magnesium Glycinate

Tends to be milder on the digestive system.
People who experience digestive issues with other forms might switch to Magnesium Glycinate.

Magnesium Oxide

Not as bioavailable as some other magnesium forms.
Despite its magnesium content, Magnesium Oxide isn't always the first choice for addressing deficiencies.

Magnesium Glycinate

A chelated form of magnesium.
Magnesium Glycinate supplements are praised for their high absorption rates.

Magnesium Oxide

Contains a high percentage of magnesium.
While Magnesium Oxide offers ample magnesium, its absorption rate can be low.

Magnesium Glycinate

Comprises magnesium and the amino acid glycine.
The presence of glycine makes Magnesium Glycinate gentler on the stomach.

Magnesium Oxide

Often used as an antacid.
For quick relief from heartburn, one might consider taking Magnesium Oxide.

Magnesium Glycinate

Commonly recommended for dietary supplementation.
Doctors might suggest Magnesium Glycinate to improve sleep and mood.

Common Curiosities

Why is Magnesium Glycinate gentler on the stomach?

Its chelated form, combined with the amino acid glycine, reduces the risk of stomach upset.

Which is better for addressing magnesium deficiencies?

Magnesium Glycinate is often preferred due to its higher bioavailability.

Can I use Magnesium Oxide for sleep or mood improvement?

It's not the typical use, but magnesium plays a role in sleep and mood, so consult a healthcare professional.

Which has a higher magnesium content?

Magnesium Oxide contains a higher percentage of magnesium, but its absorption is lower than Magnesium Glycinate.

Are both used for the same health benefits?

No, while both offer magnesium, Magnesium Oxide is often an antacid/laxative, and Magnesium Glycinate is a dietary supplement.

How do I know which form of magnesium to take?

It's best to consult a healthcare provider to determine the appropriate form based on your needs.

Is one more expensive than the other?

Prices can vary, but due to its enhanced bioavailability, Magnesium Glycinate might be priced higher.

Can I take both Magnesium Oxide and Magnesium Glycinate?

It's possible, but advisable to speak with a healthcare professional regarding dosage and interactions.

Can Magnesium Oxide cause digestive issues?

Yes, Magnesium Oxide can sometimes cause digestive discomfort, acting as a laxative.

Are there side effects to taking Magnesium Glycinate?

Any supplement can have side effects; with Magnesium Glycinate, it's typically mild and can include digestive discomfort.

How do these compounds affect heart health?

Magnesium is essential for heart health, but the exact benefits vary by form. It's best to consult with a professional.

Are there any medications that interact with these magnesium forms?

Yes, certain medications might interact. Always check with a healthcare provider or pharmacist.

Can I overdose on either form?

It's possible to consume too much magnesium, leading to symptoms like diarrhea, nausea, or more severe effects.

Is Magnesium Oxide safe for long-term use?

Generally, yes, but it's always best to monitor any supplement intake and consult with a healthcare provider.

Are there other forms of magnesium supplements available?

Yes, there are various magnesium forms, like Magnesium Citrate and Magnesium Chloride, each with unique properties and uses.

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Author Spotlight

Written by
Tayyaba Rehman
Tayyaba Rehman is a distinguished writer, currently serving as a primary contributor to askdifference.com. As a researcher in semantics and etymology, Tayyaba's passion for the complexity of languages and their distinctions has found a perfect home on the platform. Tayyaba delves into the intricacies of language, distinguishing between commonly confused words and phrases, thereby providing clarity for readers worldwide.

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