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Mutation vs. Variation — What's the Difference?

By Tayyaba Rehman — Updated on September 22, 2023
Mutation is a change in DNA sequence. On the other hand, differences in traits among individuals is called Variation . While mutations cause genetic changes, variations result from a combination of genetics and environmental factors.
Mutation vs. Variation — What's the Difference?

Difference Between Mutation and Variation

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Key Differences

A mutation refers to a change in the DNA sequence within a gene or chromosome of an organism, leading to a change in function or trait. These changes can arise due to errors during DNA replication or other processes. The Mutation might be beneficial, harmful, or neutral in its effects on the organism. On the other hand, a variation is the presence of differences in traits or characteristics among members of the same species. This Variation may arise due to genetic differences, environmental factors, or a combination of both.
While mutations are the primary source of genetic variations in populations, not all variations are caused by mutations. Some variations are the result of interactions between genes, or between genes and the environment. For instance, height variation in humans isn't solely because of a single mutation but a complex interplay of numerous genes and environmental factors like nutrition.
Furthermore, while mutations can introduce new genetic material into a population, variation is the manifestation of this genetic diversity in the population. It's the combination of all the different alleles, genes, and chromosomal arrangements. A mutation might lead to a new allele, but how this allele contributes to variation in a population depends on several factors, including its frequency and its effects on phenotype.
In essence, mutation is the mechanism, while variation is the outcome. Mutations create the potential for differences, but the observed variation in a population results from the intricate dynamics of genetics, inheritance, and environmental influence.

Comparison Chart

Definition

Change in DNA sequence
Differences in traits among individuals
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Origin

Errors in DNA replication, environmental factors
Combination of genetics and environmental factors

Manifestation

Might be harmful, beneficial, or neutral
Displays genetic diversity in a population

Examples

Sickle cell mutation in hemoglobin gene
Differences in skin color, height, and eye color among humans

Resultant Effect

Can lead to genetic disorders or be evolutionary advantageous
Represents the phenotypic range in a species

Compare with Definitions

Mutation

A permanent change in DNA.
Exposure to radiation can lead to DNA Mutation, increasing the risk of cancer.

Variation

Differences in characteristics among individuals.
The Variation in butterfly wing patterns is a result of both genetics and environment.

Mutation

Genetic change at the molecular level.
Scientists identified a novel Mutation responsible for the rare condition.

Variation

The range of phenotypic differences in a population.
Genetic Variation ensures the survival of a species in changing environments.

Mutation

A source of genetic diversity.
Beneficial Mutations can provide an advantage, driving evolution.

Variation

Deviation in traits from the norm.
The Variation in human eye colors is a fascinating study of genetics.

Mutation

In biology, a mutation is an alteration in the nucleotide sequence of the genome of an organism, virus, or extrachromosomal DNA. Viral genomes contain either DNA or RNA. Mutations result from errors during DNA or viral replication, mitosis, or meiosis or other types of damage to DNA (such as pyrimidine dimers caused by exposure to ultraviolet radiation), which then may undergo error-prone repair (especially microhomology-mediated end joining), cause an error during other forms of repair, or cause an error during replication (translesion synthesis). Mutations may also result from insertion or deletion of segments of DNA due to mobile genetic elements.Mutations may or may not produce detectable changes in the observable characteristics (phenotype) of an organism.

Variation

Observable differences in a trait's expression.
The plant shows Variation in flower color, ranging from white to deep purple.

Mutation

The act or process of being altered or changed.

Variation

A change or slight difference in condition, amount, or level, typically within certain limits
Regional variations in house prices
The figures showed marked variation from year to year

Mutation

An alteration or change, as in nature, form, or quality.

Variation

A different or distinct form or version of something
Hurling is an Irish variation of hockey

Mutation

A change in the nucleotide sequence of the genome of an organism or virus, sometimes resulting in the appearance of a new character or trait not found in the parental type.

Variation

The act, fact, or process of varying.

Mutation

The process by which such a change occurs, either through an alteration in the nucleotide sequence coding for a gene or through a change in the physical arrangement of the genetic material.

Variation

The extent or degree to which something varies
A variation of ten pounds in weight.

Mutation

The nucleotide sequence, trait, or individual that results from such a change.

Variation

Something different from another of the same type
Told a variation of an old joke.

Mutation

A change affecting a sound or a class of sounds, such as back vowels or plosive consonants, through assimilation to another sound, as in the process of umlaut.

Variation

Magnetic declination.

Mutation

A change affecting a sound or a class of sounds that is conditioned by morphological or syntactic factors rather than purely phonological factors, as in Irish, where certain words cause the lenition of the initial consonants of the following word.

Variation

(Biology) The existence within a species or other group of organisms of differences in form, function, or behavior, especially when hereditary.

Mutation

Any alteration or change.

Variation

(Mathematics) A function that relates the values of one variable to those of other variables.

Mutation

(genetics) Any heritable change of the base-pair sequence of genetic material.

Variation

A form that is an altered version of a given theme, diverging from it by melodic ornamentation and by changes in harmony, rhythm, or key.

Mutation

A mutant.

Variation

One of a series of forms based on a single theme.

Mutation

(linguistics) An alteration a particular sound of a word, especially the initial consonant, which is triggered by the word's morphological or syntactic context and not by its phonological context.

Variation

A solo dance, especially one forming part of a larger work.

Mutation

A group of thrushes.

Variation

The act of varying; a partial change in the form, position, state, or qualities of a thing.

Mutation

Change; alteration, either in form or qualities.
The vicissitude or mutations in the superior globe are no fit matter for this present argument.

Variation

A related but distinct thing.
When the process didn't work, we tried a variation.
All of his soups are variations on a single recipe.

Mutation

Gradual definitely tending variation, such as may be observed in a group of organisms in the fossils of successive geological levels.

Variation

(nautical) The angular difference at the vessel between the direction of true north and magnetic north.
Magnetic declination

Mutation

As now employed (first by de Vries), a cellular process resulting in a sudden inheritable variation (the offspring differing from its parents in some well-marked character or characters) as distinguished from a gradual variation in which the new characters become fully developed only in the course of many generations. The occurrence of mutations, the selection of strains carrying mutations permitting enhanced survival under prevailing conditions, and the mechanism of hereditary of the characters so appearing, are well-established facts; whether and to what extent the mutation process has played the most important part in the evolution of the existing species and other groups of organisms is an unresolved question.

Variation

(board games) A line of play that differs from the original.

Mutation

A variant strain of an organism in which the hereditary variant property is caused by a mutation{3}.

Variation

(music) A technique where material is repeated with alterations to the melody, harmony, rhythm, timbre, texture, counterpoint or orchestration; but with some invariant characteristic, e.g. a ground bass.

Mutation

(biology) an organism that has characteristics resulting from chromosomal alteration

Variation

(genetics) The modification of a hereditary trait.

Mutation

(genetics) any event that changes genetic structure; any alteration in the inherited nucleic acid sequence of the genotype of an organism

Variation

(astronomy) Deviation from the mean orbit of a heavenly body.

Mutation

A change or alteration in form or qualities

Variation

The act of varying; a partial change in the form, position, state, or qualities of a thing; modification; alteration; mutation; diversity; deviation; as, a variation of color in different lights; a variation in size; variation of language.
The essences of things are conceived not capable of any such variation.

Mutation

An alteration in genetic material.
A specific Mutation in the BRCA1 gene is linked to breast cancer.

Variation

Extent to which a thing varies; amount of departure from a position or state; amount or rate of change.

Mutation

A deviation from the standard DNA sequence.
The Mutation caused a malfunctioning protein, leading to disease.

Variation

Change of termination of words, as in declension, conjugation, derivation, etc.

Variation

Repetition of a theme or melody with fanciful embellishments or modifications, in time, tune, or harmony, or sometimes change of key; the presentation of a musical thought in new and varied aspects, yet so that the essential features of the original shall still preserve their identity.

Variation

One of the different arrangements which can be made of any number of quantities taking a certain number of them together.

Variation

An instance of change; the rate or magnitude of change

Variation

An activity that varies from a norm or standard;
Any variation in his routine was immediately reported

Variation

A repetition of a musical theme in which it is modified or embellished

Variation

Something a little different from others of the same type;
An experimental version of the night fighter
An emery wheel is a modern variant of the grindstone
The boy is a younger edition of his father

Variation

An artifact that deviates from a norm or standard;
He patented a variation on the sandal

Variation

The angle (at a particular location) between magnetic north and true north

Variation

(astronomy) any perturbation of the mean motion or orbit of a planet or satellite (especially a perturbation of the earth's moon)

Variation

(biology) an organism that has characteristics resulting from chromosomal alteration

Variation

(ballet) a solo dance or dance figure

Variation

The act of changing or altering something slightly but noticeably from the norm or standard;
Who is responsible for these variations in taxation?

Variation

The manifestation of genetic diversity.
Variation in beak sizes among finches helped Darwin formulate his theory of evolution.

Common Curiosities

How is Variation beneficial to a species?

Variation allows populations to adapt to changing environments, ensuring survival and evolution.

Are all Mutations harmful?

No, while some mutations can be harmful, others can be neutral or even beneficial.

How are Mutations related to genetic disorders?

Specific mutations can lead to malfunctioning proteins, causing genetic disorders.

What causes a Mutation?

Mutations can arise from errors during DNA replication, environmental factors like radiation, or certain chemicals.

Does every Mutation lead to Variation?

Not necessarily. Some mutations might not result in observable changes or might not be passed to the next generation.

What factors contribute to Variation?

Genetic differences, environmental influences, and their interactions contribute to Variation.

How is Variation observed in nature?

Variation can be seen in differences in traits like color, size, behavior, etc., among individuals.

Can a Mutation be reversed?

Some mutations can revert to their original state, but these events are generally rare.

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Author Spotlight

Written by
Tayyaba Rehman
Tayyaba Rehman is a distinguished writer, currently serving as a primary contributor to askdifference.com. As a researcher in semantics and etymology, Tayyaba's passion for the complexity of languages and their distinctions has found a perfect home on the platform. Tayyaba delves into the intricacies of language, distinguishing between commonly confused words and phrases, thereby providing clarity for readers worldwide.

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