Spleen vs. Pancreas — What's the Difference?
By Urooj Arif & Maham Liaqat — Updated on April 23, 2024
The spleen, primarily involved in blood filtration and immune response, contrasts with the pancreas, which plays crucial roles in digestion and hormone production.
Difference Between Spleen and Pancreas
Table of Contents
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Key Differences
The spleen is an organ that filters blood, removes old and damaged blood cells, and helps fight infection. The pancreas, on the other hand, is essential for digesting foods and regulating blood sugar levels by producing digestive enzymes and hormones like insulin.
Functionally, the spleen stores white blood cells and platelets, boosting the immune system, whereas the pancreas secretes insulin and glucagon into the bloodstream to control glucose metabolism.
The spleen is anatomically located in the upper left part of the abdomen, adjacent to the stomach. The pancreas, however, lies behind the stomach and extends towards the left side of the abdomen, bridging the gap between the spleen and the duodenum.
In terms of medical concerns, spleen problems often involve enlargement or rupture, which can complicate infections. Conversely, the pancreas is commonly associated with conditions like pancreatitis, type 1 and type 2 diabetes, and pancreatic cancer.
Although both organs interact closely with other digestive and lymphatic system components, the spleen is part of the lymphatic system, primarily dealing with blood and immune functions. The pancreas is part of both the digestive and endocrine systems, highlighting its dual roles.
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Comparison Chart
Primary Function
Filters blood, immune defense
Digestion, hormone production
System Belonging
Lymphatic system
Digestive and endocrine systems
Common Diseases
Splenomegaly, rupture
Pancreatitis, diabetes
Hormonal Role
None
Produces insulin, glucagon
Location in Body
Upper left abdomen
Behind the stomach
Compare with Definitions
Spleen
Acts as a blood filter.
The spleen helps remove old red blood cells from circulation.
Pancreas
Regulates blood sugar.
The pancreas releases insulin to lower blood glucose levels.
Spleen
Supports immune function.
The spleen stores white blood cells to fight infection.
Pancreas
Produces digestive enzymes.
The pancreas secretes enzymes that break down fats and proteins.
Spleen
Stores platelets.
Platelets stored in the spleen are vital for blood clotting.
Pancreas
Can develop diabetes if dysfunctional.
Damage to the pancreas can lead to diabetes by impairing insulin production.
Spleen
Vulnerable to physical injury.
A ruptured spleen can occur from a severe blow to the abdomen.
Pancreas
Associated with severe conditions like cancer.
Pancreatic cancer is one of the most lethal forms of cancer.
Spleen
Responds to certain infections.
The spleen can enlarge during a mononucleosis infection.
Pancreas
Has both endocrine and exocrine functions.
Exocrine functions relate to digestion, while endocrine relates to hormone secretion.
Spleen
The spleen is an organ found in all vertebrates. Similar in structure to a large lymph node, it acts primarily as a blood filter.
Pancreas
The pancreas is an organ of the digestive system and endocrine system of vertebrates. In humans, it is located in the abdomen behind the stomach and functions as a gland.
Spleen
A large, highly vascular lymphoid organ, located in the human body to the left of the stomach below the diaphragm, that serves as a reservoir for blood, destroys old red blood cells, and contains lymphocytes that combat blood-borne antigens.
Pancreas
A long, irregularly shaped gland in vertebrates, lying behind the stomach, that secretes pancreatic juice into the duodenum and insulin, glucagon, and somatostatin into the bloodstream.
Spleen
A homologous organ or tissue in other vertebrates.
Pancreas
(anatomy) A gland near the stomach which secretes a fluid into the duodenum to help with food digestion. The fluid contains protease, carbohydrase and lipase, which breaks down larger molecules into smaller pieces. The pancreas also produces the hormones insulin and glucagon which regulate blood sugar. These hormones are released into the cardiovascular system.
Spleen
(Obsolete) This organ conceived as the seat of emotions or passions.
Pancreas
The sweetbread, a gland connected with the intestine of nearly all vertebrates. It is usually elongated and light-colored, and its secretion, called the pancreatic juice, is discharged, often together with the bile, into the upper part of the intestines, and is a powerful aid in digestion. See Illust. of Digestive apparatus.
Spleen
Ill temper
Vent one's spleen.
Pancreas
A large elongated exocrine gland located behind the stomach; secretes pancreatic juice and insulin
Spleen
(Archaic) Melancholy.
Spleen
(Obsolete) A whim; a caprice.
Spleen
In vertebrates, including humans, a ductless vascular gland, located in the left upper abdomen near the stomach, which destroys old red blood cells, removes debris from the bloodstream, acts as a reservoir of blood, and produces lymphocytes.
Spleen
A bad mood; spitefulness.
Spleen
A sudden motion or action; a fit; a freak; a whim.
Spleen
(obsolete) Melancholy; hypochondriacal affections.
Spleen
A fit of immoderate laughter or merriment.
Spleen
To dislike.
Spleen
To annoy or irritate.
Spleen
(ambitransitive) To complain; to rail; to vent one's spleen.
Spleen
To remove the spleen, or, by extension, to gore.
Spleen
To excise or remove.
Spleen
A peculiar glandlike but ductless organ found near the stomach or intestine of most vertebrates and connected with the vascular system; the milt. Its exact function in not known.
Spleen
Anger; latent spite; ill humor; malice; as, to vent one's spleen.
In noble minds some dregs remain,Not yet purged off, of spleen and sour disdain.
Spleen
A fit of anger; choler.
Spleen
A sudden motion or action; a fit; a freak; a whim.
A thousand spleens bear her a thousand ways.
Spleen
Melancholy; hypochondriacal affections.
Bodies changed to various forms by spleen.
There is a luxury in self-dispraise:And inward self-disparagement affordsTo meditative spleen a grateful feast.
Spleen
A fit of immoderate laughter or merriment.
Thy silly thought enforces my spleen.
Spleen
To dislke.
Spleen
A large dark-red oval organ on the left side of the body between the stomach and the diaphragm; produces cells involved in immune responses
Spleen
A feeling of resentful anger
Common Curiosities
What is the main function of the spleen?
The spleen primarily filters the blood and helps the immune system by removing old blood cells and storing white blood cells and platelets.
What are common diseases associated with the pancreas?
Common pancreatic diseases include pancreatitis, pancreatic cancer, and diabetes.
How does the spleen impact the immune system?
The spleen stores white blood cells which play a crucial role in fighting infection.
What hormones does the pancreas produce?
The pancreas produces insulin and glucagon, which are vital for glucose metabolism.
What is the difference in the location between the spleen and pancreas?
The spleen is located in the upper left part of the abdomen near the stomach, while the pancreas lies behind the stomach extending toward the left side of the abdomen.
What is pancreatitis and how is it related to the pancreas?
Pancreatitis is the inflammation of the pancreas, which can be acute or chronic and significantly affects digestive and hormonal functions.
Can you live without a spleen or pancreas?
Yes, people can live without a spleen with certain medical precautions; living without a pancreas requires lifelong management of digestive and endocrine functions.
How do spleen and pancreas diseases affect overall health?
Diseases of these organs can severely impact health, affecting immune response and metabolic stability respectively.
How does the spleen respond to infections like mononucleosis?
The spleen often enlarges in response to infections such as mononucleosis, indicating an active immune response.
What happens if the spleen is removed?
Removal of the spleen requires lifetime precautions against infections due to reduced immune function.
What preventive care is recommended for spleen health?
Preventive care includes vaccinations and careful monitoring of activities to avoid injury to the abdomen, especially in sports or physical activities.
What makes the pancreas unique in the human body?
Its dual role in both the digestive and endocrine systems, impacting digestion and glucose regulation, makes it unique.
What are the surgical implications for spleen vs. pancreas issues?
Surgical interventions for spleen issues typically involve removal in cases of rupture, whereas pancreatic surgery can involve complex procedures like the Whipple procedure for cancer.
Can the functions of the pancreas be medically replaced?
Pancreatic functions, particularly insulin production, can be medically managed with insulin injections and enzyme supplements.
Is the spleen larger than the pancreas?
No, the pancreas is generally larger and extends across a greater portion of the abdomen than the spleen.
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Written by
Urooj ArifUrooj is a skilled content writer at Ask Difference, known for her exceptional ability to simplify complex topics into engaging and informative content. With a passion for research and a flair for clear, concise writing, she consistently delivers articles that resonate with our diverse audience.
Co-written by
Maham Liaqat