Transresveratrol vs. Resveratrol — What's the Difference?

A naturally occurring isomer of resveratrol known for its potent antioxidant and anti-inflammatory properties.

Exhibits antioxidant properties that may vary depending on the specific isomer present.

The active form of resveratrol that is more easily absorbed by the human body.

Known for its presence in red wine, often discussed in the context of the French paradox.

Associated with the potential reduction of heart disease risk.

A stilbenoid, a type of natural phenol, produced by several plants in response to injury or when the plant is under attack by pathogens.

Commonly found in the skin of red grapes and certain berries.

Investigated for potential benefits in anti-aging and disease prevention.

Studied for its role in protecting against cognitive decline.

Can be administered in various forms, including supplements and topical solutions.

The trans isomer of resveratrol.

Resveratrol (3,5,4′-trihydroxy-trans-stilbene) is a stilbenoid, a type of natural phenol, and a phytoalexin produced by several plants in response to injury or when the plant is under attack by pathogens, such as bacteria or fungi. Sources of resveratrol in food include the skin of grapes, blueberries, raspberries, mulberries, and peanuts.Although commonly used as a dietary supplement and studied in laboratory models of human diseases, there is no high-quality evidence that resveratrol improves lifespan or has a substantial effect on any human disease.

A polyphenolic compound, C14H12O3, that is found in grapes, mulberries, peanuts, and other plants or food products, especially red wine, has antioxidant and anti-inflammatory properties, and may protect against cancer and cardiovascular disease.

A phenolic substance, 3,5,4'-trihydroxystilbene, a stilbenoid and phytoalexin, that is found in some fruits and nuts, and in red wine, and is reputed to have some beneficial properties for humans.

Some studies suggest that resveratrol can aid in weight management by enhancing fat metabolism and reducing inflammation, though results can vary depending on the form and dosage.

Resveratrol is known for its antioxidant properties, potential cardiovascular benefits, anti-aging effects, and its role in reducing the risk of certain diseases.

Trans-resveratrol is absorbed more efficiently by the body compared to its cis counterpart, partly due to its chemical structure that allows easier passage through cellular membranes.

Trans-resveratrol is primarily found in the skin of red grapes, berries like blueberries and cranberries, and in peanuts.

Dosages in studies vary widely, but most suggest that moderate amounts, typically between 150-500 mg per day, can be beneficial, though consulting a healthcare provider is recommended.

Yes, cooking can reduce the resveratrol content in foods, especially through processes that involve prolonged heating or boiling.

While generally safe, trans-resveratrol supplements can cause digestive disturbances in some people, especially at high doses.

Yes, resveratrol's antioxidant properties contribute to skin health by protecting the skin from damage and improving skin vitality and appearance.

Trans-resveratrol is generally considered more effective due to its higher bioavailability and stronger biological activity compared to other isomers found in resveratrol.

Consuming foods rich in trans-resveratrol like red grapes, blueberries, and cranberries, and choosing red wine in moderation, are natural ways to increase intake.

Yes, both compounds have been studied for their effects on cardiovascular health, but trans-resveratrol is often preferred in research due to its higher potency.

Trans-resveratrol generally has a higher antioxidant capacity due to its stable configuration that effectively scavenges harmful free radicals compared to other forms of resveratrol.

Trans-resveratrol can interact with certain medications, particularly blood thinners and drugs metabolized by the liver; consultation with a healthcare provider is advised before starting supplements.

Studies, primarily in yeast, worms, and mice, suggest that resveratrol can extend lifespan by mimicking the effects of caloric restriction, though evidence in humans is still inconclusive.

Resveratrol has been shown to have potential neuroprotective effects, possibly improving cognitive function and reducing the risk of neurodegenerative diseases.

Trans-resveratrol has demonstrated significant anti-inflammatory effects, which are believed to contribute to its various health benefits, including reducing the risk of chronic diseases.